Nanoknife is a brand-new cutting-edge ablation technology for tumor
treatment. It breaks the membrane of tumor cells with high voltage pulses from
electrode probes, resulting in
multiple irreversible nano-meter electroporated
holes, which is applicable to pancreatic cancer, liver cancer and other solid
tumor treatments.
What’s Nanoknife
Nanoknife is a brand-new cutting-edge ablation
technology for tumor treatment. Derived from Irreversible Electroporation (IRE), it breaks the membrane of tumor cells with high voltage pulses from
electrode probes, resulting in
multiple irreversible nano-meter electroporated
holes. Thus, it destroys the balance in and between tumor cells and accelerates
their death.
Clinical Application of Nanoknife
Nanoknife was approved by US FDA into
clinical use in October, 2011 and has passed EU CE accreditation. In recently
years, it has been successively put into clinical use in over 100 core cancer hospitals
around the world, including China, whose Ministry of Health approved in June,
2015 the use of this technology in cancer treatment.
Advantages of Nanoknife
Short course of ablation
To ablate a solid
tumor of 3cm in diameter, 5 minutes is more than enough. Every pair of probes
releases 90 microsecond ultra-short pulses, which
takes less than one minute. Even if there are 3-4 overlapped ablation areas,
some patients can still be discharged the same day or next day after the whole
process.
Vessels, nerves and other vital tissues
in the ablated area are well protected.
Another advantage
of nanoknife ablation is that it causes in the ablated area no irreversible
damage to important tissue structures like vessels, bile duct, nerves and ureter, etc.. All important tissue
structures within liver, such as artery, vein, portal vein, bile duct, etc.
will be well reserved after nanoknife operation.
Non-thermal ablation
The ablation of
nanoknife breaks cell membrane using mainly electrical pulses, without creating
thermal energy during the process, while traditional ablation uses temperature
alternation to cause protein denaturation, damaging all kinds of protein and
DNA, and consequently makes above mentioned tissue structures irreparable. Moreover,
if there are major vessels in the ablated area, the thermal energy of
traditional ablation will be taken away by the bloodstream and the ablation
effect will be weaken, thus, recurrence is more likely to happen.
Thorough treatment, clear boundary
Another advantage
of nanoknife is that its ablation can completely cover the tumor no matter
where it is located and in what sizes and shape. Meanwhile, after ablation,
there is clear boundary between the ablated and unablated area,
which means no residual lesion and therefore lower risk of recurrence.
Normal cells occupy the ablated area
shortly to restore its normal function
Traditional
ablation use temperature alternation to trigger protein denaturation, resulting
in coagulative necrosis, after which no tissue structure in the area survives. On
the contrary, nanoknife is to induce death of tumor cells and use phagocytosis
of immune cells of human body to eliminate the dead tissues, thus to repair and
regenerate normal tissues.
Real-time monitoring on the process
Nanoknife treatment
can be guided and monitored under ultrasound, CT and MRI. With assistance of these
equipments, the nanoknife probes are located, process and actual range of
ablation area are monitored in real time. Thus, doctors can observe the changes
of the ablated area and around tissues to ensure the treatment effect, safety
and quick recovery afterwards.
Adaptable to more complicated
situations
Traditional ablation is impracticable to
situations when the tumor involves major vessels, bile duct, pancreiatic duct,
portal vein and other vital areas. Moreover, there is high risk of damaging
nerves and causing paralysis, loss of sexual ability and other consequences in using traditional ablation to treat prostate tumor or
tumor near the spine. On the contrary, nanoknife does no harm to the ducts and
nerves, therefore it is practicable to above mentioned situations and plays an irreplaceable
role in treating patients of this kind.
Adaptable to illnesses
Illnesses can be treated with
nanoknife include tumors in pancreas, liver, lung, kidney, prostate, etc.. It
is of particular advantages in dealing with tumors involving porta hepatis,
gallbladder, bile duct, pancreas and ureter.
Cautions
1)
During the process, general anesthesia
and tracheal intubation are needed. Because the released millisecond
high-voltage electrical pulses may cause muscle vibration, muscle relaxants are
also required.
2)
For patients who have near
the tumor implanted metal objects, including stents, radioactive particles, heart pacemaker
etc. and those who have arrhythmia or have recently experienced myocardial infarction,
nanoknife is impracticable.
Nana knife
is the advanced tumor treatment technology at Modern Cancer Hopsital Guangzhou.
It is applicable to treat the tumor near hepatic portal, gallbladder, bile
duct, pancreas or ureter, which brings more treatment options to cancer
patients.
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